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| Item Type: | Article |
|---|---|
| Title: | The association of pre-operative biomarkers of endothelial dysfunction with the risk of post-operative neurocognitive disorders: results from the BioCog study |
| Creators Name: | Moazzen, S., Janke, J., Slooter, A.J.C., Winterer, G., Spies, C., Pischon, T. and Feinkohl, I. |
| Abstract: | INTRODUCTION: Endothelial dysfunction (ED) promotes the development of atherosclerosis, and studies suggest an association with age-related neurocognitive disorders. It is currently unclear whether ED is also associated with the risk of perioperative neurocognitive disorders. METHOD: We included 788 participants aged = 65 years of the BioCog study. Patients were scheduled to undergo elective surgery with expected duration > 60 min. Blood was collected before surgery for measurement of 5 biomarkers of ED: asymmetric and symmetric dimethylarginine (ADMA; SDMA), intercellular and vascular adhesion molecule (ICAM-1, VCAM-1), and von Willebrand factor (vWF). Patients were monitored for the occurrence of postoperative delirium (POD) daily until the 7th postoperative day. 537 (68.1%) patients returned for a 3-month follow-up. Post-operative cognitive dysfunction (POCD) was defined from the change in results on a battery of 6 neuropsychological tests between baseline and 3 months, compared to the change in results of a control group during the 3-month interval. The associations of each of the 5 ED biomarkers with POD and POCD respectively were determined using multiple logistic regression analyses with adjustment for age, sex, surgery type, pre-morbid IQ, body mass index, hypertension, diabetes, HbA1C, triglyceride, total and HDL cholesterol. RESULTS: 19.8% of 788 patients developed POD; 10.1% of 537 patients had POCD at 3 months. Concentrations of ED biomarkers were not significantly associated with a POD. A higher VCAM-1 concentration was associated with a reduced POCD risk (adjusted odds ratio 0.55; 95% CI: 0.35-0.86). No further statistically significant results were found. CONCLUSION: Pre-operative concentrations of ED biomarkers were not associated with POD risk. We unexpectedly found higher VCAM-1 to be associated with a reduced POCD risk. Further studies are needed to evaluate these findings. |
| Keywords: | Ageing, Surgery, Endothelial Function, Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Dysfunction, Postoperative Cognitive Complications, Neuropsychological Tests, Endothelial Dysfunction, Biomarkers |
| Source: | BMC Anesthesiology |
| ISSN: | 1471-2253 |
| Publisher: | BioMed Central |
| Volume: | 24 |
| Number: | 1 |
| Page Range: | 358 |
| Date: | 8 October 2024 |
| Official Publication: | https://doi.org/10.1186/s12871-024-02722-3 |
| PubMed: | View item in PubMed |
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