Molecular and cellular mechanisms of motor circuit development

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Item Type:	Review
Title:	Molecular and cellular mechanisms of motor circuit development
Creators Name:	Kratsios, P., Zampieri, N., Carrillo, R., Mizumoto, K., Sweeney, L.B. and Philippidou, P.
Abstract:	Motor circuits represent the main output of the central nervous system and produce dynamic behaviors ranging from relatively simple rhythmic activities like swimming in fish and breathing in mammals to highly sophisticated dexterous movements in humans. Despite decades of research, the development and function of motor circuits remain poorly understood. Breakthroughs in the field recently provided new tools and tractable model systems that set the stage to discover the molecular mechanisms and circuit logic underlying motor control. Here, we describe recent advances from both vertebrate (mouse, frog) and invertebrate (nematode, fruit fly) systems on cellular and molecular mechanisms that enable motor circuits to develop and function and highlight conserved and divergent mechanisms necessary for motor circuit development.
Keywords:	Development, Interneurons, Motor Circuits, Motor Neurons, Spinal Cord, Synaptic Specificity, Terminal Selectors, Animals
Source:	Journal of Neuroscience
ISSN:	0270-6474
Publisher:	Society for Neuroscience
Volume:	44
Number:	40
Page Range:	e1238242024
Date:	2 October 2024
Official Publication:	https://doi.org/10.1523/jneurosci.1238-24.2024
PubMed:	View item in PubMed

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