Das visuelle System als Modell in der translationalen Forschung [The visual system as a model in translational research]

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Item Type:	Article
Title:	Das visuelle System als Modell in der translationalen Forschung [The visual system as a model in translational research]
Creators Name:	Sindi, M., Oertel, F.C., Paul, F., Meuth, S.G. and Albrecht, P.
Abstract:	The visual system provides unique insights into the complex mechanisms of neurological diseases, thus serving as a central model in translational research. The retina, as part of the central nervous system, acts as a precise window that enables the study of neurodegenerative and neuroinflammatory processes. This article highlights the application of the visual system in the translational research of neurological diseases through various experimental models and analytical methods. Special emphasis is placed on the examination of inflammatory models such as Experimental Autoimmune Encephalomyelitis Optic Neuritis (EAEON), non-inflammatory degenerative models like Optic Nerve Crush and light-induced photoreceptor loss, as well as demyelinating models like the Cuprizone model, in addition to neurodegenerative diseases such as Alzheimer's type dementia and idiopathic Parkinson's syndrome. The article also presents diagnostic and functional evaluation methods such as Optical Coherence Tomography (OCT), confocal Scanning Laser Ophthalmoscopy (cSLO), optomotor response (OMR) measurements, and the measurement of Visually Evoked Potentials (VEP). Furthermore, a brief outlook is provided, as well as the limitations, especially regarding the extrapolatability of results from animal models to humans and vice versa.
Keywords:	OCT, VEP, Visual System, Retina, Translational Evaluation Methods
Source:	Klinische Neurophysiologie
ISSN:	1434-0275
Publisher:	Thieme
Volume:	55
Number:	03
Page Range:	139-146
Number of Pages:	8
Date:	September 2024
Official Publication:	https://doi.org/10.1055/a-2331-0668

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