![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
| Item Type: | Article |
|---|---|
| Title: | The big chill: growth of in situ structural biology with cryo-electron tomography |
| Creators Name: | Kudryashev, M. |
| Abstract: | In situ structural biology with cryo-electron tomography (cryo-ET) and subtomogram averaging (StA) is evolving as a major method to understand the structure, function, and interactions of biological molecules in cells in a single experiment. Since its inception, the method has matured with some stellar highlights and with further opportunities to broaden its applications. In this short review, I want to provide a personal perspective on the developments in cryo-ET as I have seen it for the last ~20 years and outline the major steps that led to its success. This perspective highlights cryo-ET with my eyes as a junior researcher and my view on the present and past developments in hardware and software for in situ structural biology with cryo-ET. |
| Source: | QRB Discovery |
| ISSN: | 2633-2892 |
| Publisher: | Cambridge University Press |
| Volume: | 5 |
| Page Range: | e10 |
| Date: | 13 December 2024 |
| Official Publication: | https://doi.org/10.1017/qrd.2024.10 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
