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| Item Type: | Article |
|---|---|
| Title: | New phenanthrenequinones from Cymbidium ensifolium roots and their anti-inflammatory activity on lipopolysaccharide-activated BV2 microglial cells |
| Creators Name: | Thant, M.T., Hasriadi, H., Poldorn, P., Jungsuttiwong, S., Rojsitthisak, P., Böttcher, C., Towiwat, P. and Sritularak, B. |
| Abstract: | The roots of Cymbidium ensifolium yielded a total of 17 compounds, comprising two new compounds (1-2), one new natural product (3), and 14 known compounds (4-17). The structures of new compounds were determined through the analysis of their spectroscopic data, including NMR, MS, UV, FT-IR, optical rotation, and CD. The anti-inflammatory activity of the isolated pure compounds was assessed using lipopolysaccharide-activated BV2 microglial cells. Compounds 1, 3, 6, 12, 14, and 16 showed the ability to reduce LPS induced NO release in BV2 microglial cells, with IC(50) values of 9.95 ± 2.13, 8.77 ± 3.78, 2.39 ± 0.91, 6.69 ± 2.94, 2.96 ± 1.38, 8.42 ± 2.99 μM, respectively and reduced the secretion of proinflammatory mediators (TNF-α, IL-6, MCP-1) in a concentration-dependent manner. Furthermore, the mechanistic role of the compound 3 was determined, which demonstrated its ability to inhibit the nuclear factor-κB (NF-κB) pathway through decreasing phosphorylation of p65 subunits. |
| Source: | RSC Advances |
| ISSN: | 2046-2069 |
| Publisher: | Royal Society of Chemistry |
| Volume: | 14 |
| Number: | 39 |
| Page Range: | 28390-28400 |
| Date: | 5 September 2024 |
| Official Publication: | https://doi.org/10.1039/d4ra04761c |
| PubMed: | View item in PubMed |
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