Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses

Tools

Preview	PDF (Publisher's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 2MB
	MS Word (Supplementary Data) 30kB

Item Type:	Article
Title:	Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses
Creators Name:	Bartho, L.A., Walker, S.P., Cannon, P., Nguyen, T.V., Nguyen, A., Botha, S.M., Hannan, N.J., Tong, S. and Kaitu'u-Lino, T.J.
Abstract:	Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR1 in placentas from preeclamptic or small for gestational age (SGA) pregnancies, and placental explant model (1 % O(2), IL6 and TNFα, or control). LAIR1 mRNA was reduced in placentas from preeclamptic (p < 0.0001, n = 78) and SGA (p < 0.0001, n = 32) pregnancies. LAIR1 protein expression was reduced in placentas from preeclampsia (p < 0.0001, n = 43) and SGA (p = 0.009, n = 10) pregnancies. Hypoxia (1 % O(2)) reduced LAIR1 mRNA expression in placental explants (p = 0.008). These findings suggest hypoxia modulates LAIR1 expression in the placenta.
Keywords:	LAIR1, FGR, SGA, Preeclampsia, Placenta, Hypoxia
Source:	Placenta
ISSN:	0143-4004
Publisher:	Elsevier
Volume:	156
Page Range:	10-13
Date:	October 2024
Official Publication:	https://doi.org/10.1016/j.placenta.2024.08.018
PubMed:	View item in PubMed

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year