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| Item Type: | Article |
|---|---|
| Title: | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses |
| Creators Name: | Bartho, L.A., Walker, S.P., Cannon, P., Nguyen, T.V., Nguyen, A., Botha, S.M., Hannan, N.J., Tong, S. and Kaitu'u-Lino, T.J. |
| Abstract: | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR1 in placentas from preeclamptic or small for gestational age (SGA) pregnancies, and placental explant model (1 % O(2), IL6 and TNFα, or control). LAIR1 mRNA was reduced in placentas from preeclamptic (p < 0.0001, n = 78) and SGA (p < 0.0001, n = 32) pregnancies. LAIR1 protein expression was reduced in placentas from preeclampsia (p < 0.0001, n = 43) and SGA (p = 0.009, n = 10) pregnancies. Hypoxia (1 % O(2)) reduced LAIR1 mRNA expression in placental explants (p = 0.008). These findings suggest hypoxia modulates LAIR1 expression in the placenta. |
| Keywords: | LAIR1, FGR, SGA, Preeclampsia, Placenta, Hypoxia |
| Source: | Placenta |
| ISSN: | 0143-4004 |
| Publisher: | Elsevier |
| Volume: | 156 |
| Page Range: | 10-13 |
| Date: | October 2024 |
| Official Publication: | https://doi.org/10.1016/j.placenta.2024.08.018 |
| PubMed: | View item in PubMed |
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