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| Item Type: | Article |
|---|---|
| Title: | Cell cycle regulation of nuclear factor p92 DNA binding activity by novel phase specific inhibitors |
| Creators Name: | Grinstein, E., Weinert, I., Droese, B., Pagano, M. and Royer, H.D. |
| Abstract: | The nuclear factor p92, originally discovered by its interaction with the human papillomavirus type 18 enhancer, is a cellular protein whose activity is restricted to S phase in human primary fibroblasts. The human papillomavirus type 18 p92 binding sequence confers enhancer activity on a heterologous promoter, suggesting that p92 acts as a transcription factor. We have identified a class of nuclear inhibitory proteins, I-92s, which noncovalently associate with p92 but not with other transcription factors such as AP1, E2F, or NF-kappaB. Different I-92s occur in G1, G2, and G0, while no I-92 is detectable in S phase. Phase-specific inhibitors, therefore, are responsible for the cell cycle dependence of p92 activity and provide a novel mechanism linking transcription factor regulation with the cell cycle. |
| Keywords: | Base Sequence, Binding Sites, Cell Cycle, Cell Nucleus, Cultured Cells, DNA-Binding Proteins, Fibroblasts, Flow Cytometry, Genetic Enhancer Elements, Genetic Promoter Regions, HeLa Cells, Molecular Sequence Data, Nuclear Proteins, Oligodeoxyribonucleotides, Papillomaviridae, Recombinant Proteins, S Phase, Simian Virus 40, Transcription Factors, Transfection |
| Source: | Journal of Biological Chemistry |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Volume: | 271 |
| Number: | 16 |
| Page Range: | 9215-9222 |
| Date: | 19 April 1996 |
| Official Publication: | https://doi.org/10.1074/jbc.271.16.9215 |
| PubMed: | View item in PubMed |
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