Dynamics of cell surface molecules during T cell recognition

Tools

Item Type:	Review
Title:	Dynamics of cell surface molecules during T cell recognition
Creators Name:	Davis, M.M., Krogsgaard, M., Huppa, J.B., Sumen, C., Purbhoo, M.A., Irvine, D.J., Wu, L.C. and Ehrlich, L.
Abstract:	Recognition of foreign antigens by T lymphocytes is a very important component of vertebrate immunity-vital to the clearance of pathogenic organisms and particular viruses and necessary, indirectly, for the production of high affinity antibodies. T cell recognition is mediated by the systematic scanning of cell surfaces by T cells, which collectively express many antigen receptors. When the appropriate antigenic peptide bound to a molecule of the major histocompatibility complex is found-even in minute quantities-a series of elaborate cell-surface molecule and internal rearrangements take place. The sequence of events and the development of techniques required to observe these events have significantly enhanced our understanding of T cell recognition and may find application in other systems of transient cell:cell interactions as well.
Keywords:	T Lymphocytes, Cell:Cell Recognition, Cell Surface Molecules, T Cell Receptors, Immunological Synapse, Animals
Source:	Annual review of biochemistry
ISSN:	0066-4154
Publisher:	Annual Reviews
Volume:	72
Page Range:	717-42
Date:	July 2003
Official Publication:	https://doi.org/10.1146/annurev.biochem.72.121801.161625
PubMed:	View item in PubMed

Repository Staff Only: item control page