T-cell-antigen recognition and the immunological synapse

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Item Type:	Review
Title:	T-cell-antigen recognition and the immunological synapse
Creators Name:	Huppa, J.B. and Davis, M.M.
Abstract:	Much excitement of the past five years in the area of T-cell-antigen recognition has centred around the immunological synapse — a complex cellular structure that forms at the interface of a T cell and a cell that expresses the appropriate peptide–MHC complexes. Thanks to new imaging technologies, we are now beginning to understand the role of cell-surface molecules and some of their attendant signalling modules in the context of cell-to-cell communication. Progress has been so rapid that T-cell-antigen recognition might be the first system in which the molecular basis of cell–cell recognition is understood.
Keywords:	Antigen-Presenting Cells, Cell Communication, Fluorescence Resonance Energy Transfer, Lymphocyte Activation, Confocal Microscopy, Fluorescence Microscopy, T-Cell Antigen Receptors, T-Lymphocytes, T-Lymphocytes / Immunology, Animals, Mice
Source:	Nature Reviews Immunology
ISSN:	1474-1733
Publisher:	Nature Publishing Group
Volume:	3
Number:	12
Page Range:	973-83
Date:	1 December 2003
Official Publication:	https://doi.org/10.1038/nri1245
PubMed:	View item in PubMed

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