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| Item Type: | Article |
|---|---|
| Title: | The lack of synapsin alters presynaptic plasticity at hippocampal mossy fibers in male mice |
| Creators Name: | Bruentgens, F., Velasquez, L.M., Stumpf, A., Parthier, D., Breustedt, J., Benfenati, F., Milovanovic, D., Schmitz, D. and Orlando, M. |
| Abstract: | Synapsins are highly abundant presynaptic proteins that play a crucial role in neurotransmission and plasticity via the clustering of synaptic vesicles. The synapsin III isoform is usually downregulated after development, but in hippocampal mossy fiber boutons it persists in adulthood. Mossy fiber boutons express presynaptic forms of short- and long-term plasticity, which are thought to underlie different forms of learning. Previous research on synapsins at this synapse focused on synapsin isoforms I and II. Thus, a complete picture regarding the role of synapsins in mossy fiber plasticity is still missing. Here, we investigated presynaptic plasticity at hippocampal mossy fiber boutons by combining electrophysiological field recordings and transmission electron microscopy in a mouse model lacking all synapsin isoforms. We found decreased short-term plasticity - i.e. decreased facilitation and post-tetanic potentiation - but increased long-term potentiation in male synapsin triple knockout mice. At the ultrastructural level, we observed more dispersed vesicles and a higher density of active zones in mossy fiber boutons from knockout animals. Our results indicate that all synapsin isoforms are required for fine regulation of short- and long-term presynaptic plasticity at the mossy fiber synapse. |
| Keywords: | Excitatory Postsynaptic Potentials, Inbred C57BL Mice, Knockout Mice, Hippocampal Mossy Fibers, Neuronal Plasticity, Presynaptic Terminals, Synapsins, Synaptic Vesicles, Animals, Mice |
| Source: | eNeuro |
| ISSN: | 2373-2822 |
| Publisher: | Society for Neuroscience |
| Volume: | 11 |
| Number: | 7 |
| Page Range: | ENEURO.0330-23.2024 |
| Date: | July 2024 |
| Official Publication: | https://doi.org/10.1523/ENEURO.0330-23.2024 |
| PubMed: | View item in PubMed |
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