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Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice

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Item Type:Article
Title:Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice
Creators Name:Rother, F., Depping, R., Popova, E., Huegel, S., Heiler, A., Hartmann, E. and Bader, M.
Abstract:The nuclear transport of proteins plays an important role in mediating the transition from egg to embryo and distinct karyopherins have been implicated in this process. Here, we studied the impact of KPNA2 deficiency on preimplantation embryo development in mice. Loss of KPNA2 results in complete arrest at the 2cell stage and embryos exhibit the inability to activate their embryonic genome as well as a severely disturbed nuclear translocation of Nucleoplasmin 2. Our findings define KPNA2 as a new maternal effect gene.
Keywords:Female Fertility, Importin, Karyopherin, Preimplantation Development, Animals, Mice
Source:FASEB Journal
ISSN:0892-6638
Publisher:Federation of American Societies for Experimental Biology
Volume:38
Number:8
Page Range:e23623
Date:30 April 2024
Official Publication:https://doi.org/10.1096/fj.202301572rr
PubMed:View item in PubMed

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