The topology of transcription by immobilized polymerases

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Item Type:	Article
Title:	The topology of transcription by immobilized polymerases
Creators Name:	Iborra, F.J., Pombo, A., McManus, J., Jackson, D.A. and Cook, P.R.
Abstract:	Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a polymerase immobilized in a large transcription factory. The evidence for immobilized polymerases is reviewed, and a model for transcription by such fixed enzymes is presented. According to the model, gene activation would involve reducing gene-factory distance and increasing the affinity of a promoter for a factory. Locus controlling regions and enhancers would attach to a factory and increase the chances that a promoter could bind to a polymerase; after transcriptional termination, the gene would detach from the factory. As some RNA processing occurs cotranscriptionally, processing sites are also likely to be associated with the factory.
Keywords:	DNA, DNA-Directed RNA Polymerases, Gene Expression Regulation, Genetic Models, Genetic Promoter Regions, Genetic Transcription, Immobilized Enzymes, Post-Transcriptional RNA Processing, RNA, Transcriptional Activation
Source:	Experimental Cell Research
ISSN:	0014-4827
Publisher:	Academic Press
Volume:	229
Number:	2
Page Range:	167-173
Date:	15 December 1996
Official Publication:	https://doi.org/10.1006/excr.1996.0355
PubMed:	View item in PubMed

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