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| Item Type: | Article |
|---|---|
| Title: | Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo |
| Creators Name: | Wynn, T.A., Morawetz, R., Scharton-Kersten, T., Hieny, S., Morse III, H.C., Kühn, R., Müller, W., Cheever, A.W. and Sher, A. |
| Abstract: | In response to i.v.-injected eggs of Schistosoma mansoni, normal mice develop a dominant type 2 response, whereas IL-10-deficient animals generate a mixed type 1/type 2 cytokine profile and show reduced pulmonary granuloma formation. IL-4-deficient mice, while displaying diminished type 2 responses and granulomatous inflammation, also do not fully default to a type 1 cytokine profile. Strikingly, mice doubly deficient in IL-4 and IL-10 are completely defective in pulmonary granuloma formation and develop a highly polarized type 1 cytokine pattern. In analogous fashion, mice deficient in both IL-12 and IL-10 generate highly exacerbated type 2 cytokine responses, whereas in wild-type animals, IL-12 depletion minimally effects egg-induced cytokine production. Together, these results argue first that IL-10 is an important endogenous down-regulator of type 2 as well as type 1 cytokine synthesis, and second, that its induction is critical for type 2 response polarization in vivo. |
| Keywords: | Cytokines, Granuloma, Inbred C57BL Mice, Interleukin-10, Interleukin-12, Interleukin-4, Knockout Mice, Monoclonal Antibodies, Parasitic Lung Diseases, Schistosomiasis, Th1 Cells, Th2 Cells, Animals, Mice |
| Source: | Journal of Immunology |
| ISSN: | 0022-1767 |
| Publisher: | American Association of Immunologists |
| Volume: | 159 |
| Number: | 10 |
| Page Range: | 5014-5023 |
| Date: | November 1997 |
| Official Publication: | https://doi.org/10.4049/jimmunol.159.10.5014 |
| PubMed: | View item in PubMed |
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