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Synthesis of GTP-derived Ras ligands

Item Type:Article
Title:Synthesis of GTP-derived Ras ligands
Creators Name:Soulère, L., Aldrich, C., Daumke, O., Gail, R., Kissau, L., Wittinghofer, A. and Waldmann, H.
Abstract:A practical and convenient method for the synthesis of acid- and base-sensitive GTP analogues carrying a further substituent at the terminal phosphate has been developed. Key to the successful synthesis of these potential ligands of the Ras protein is the use of Pd0-sensitive allyl protecting groups in a one-pot synthesis that avoids evaporation steps. Initial biochemical analysis of a representative compound revealed that such GTP analogues can bind to Ras and might open up the possibility of developing small molecules that can act as deactivators of oncogenic Ras.
Keywords:Bioorganic Chemistry, Nucleotides, Protecting Groups, Ras Protein, Signal Transduction
Source:ChemBioChem
ISSN:1439-4227
Publisher:Wiley-VCH
Volume:5
Number:10
Page Range:1448-53
Date:4 October 2004
Official Publication:https://doi.org/10.1002/cbic.200400133
PubMed:View item in PubMed

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