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| Item Type: | Article |
|---|---|
| Title: | New phenolic glycosides from Coelogyne fuscescens Lindl. var. brunnea and their cytotoxicity against human breast cancer cells |
| Creators Name: | Thant, M.T., Bhummaphan, N., Wuttiin, J., Puttipanyalears, C., Chaichompoo, W., Rojsitthisak, P., Punpreuk, Y., Böttcher, C., Likhitwitayawuid, K. and Sritularak, B. |
| Abstract: | The phytochemical investigation of the whole plants of Coelogyne fuscescens Lindl. var. brunnea led to the discovery of three new phenolic glycosides, i.e., coelofusides A–C and 12 known compounds. For the first time, we reported the nuclear magnetic resonance (NMR) data of 4-O-(6'-O-glucosyl-4"-hydroxybenzoyl)-4-hydroxybenzyl alcohol in this study. The identification of the structures of newly discovered compounds was done through the analysis of their spectroscopic data [NMR, mass spectrometry, ultraviolet, Fourier transform infrared, optical rotation, and circular dichroism (CD)]. In comparison to anticancer drugs (i.e., etoposide and carboplatin), we evaluated anticancer potential of the isolated compounds on two different breast cancer cell lines, namely, T47D and MDA-MB-231. Human fibroblast HaCaT cells were used as the control cells. After a 48 h incubation, flavidin, coelonin, 3,4-dihydroxybenzaldehyde, and oxoflavidin showed significant cytotoxic effects against breast cancer cells. Among them, oxoflavidin exhibited the most potent cytotoxicity on MDA-MB-231 with an IC(50) value of 26.26 ± 4.33 μM. In the nuclear staining assay, oxoflavidin induced apoptosis after 48 h in both T47D and MDA-MB-231 cells in a dose-dependent manner. Furthermore, oxoflavidin upregulated the expression of apoptotic genes, such as p53, Bax, poly(ADP-ribose) polymerase, caspase-3, and caspase-9 genes while significantly decreasing antiapoptotic protein (Bcl-2) expression levels. |
| Source: | ACS Omega |
| ISSN: | 2470-1343 |
| Publisher: | American Chemical Society |
| Volume: | 9 |
| Number: | 7 |
| Page Range: | 7679−7691 |
| Date: | 20 February 2024 |
| Official Publication: | https://doi.org/10.1021/acsomega.3c07048 |
| PubMed: | View item in PubMed |
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