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| Item Type: | Preprint |
|---|---|
| Title: | Osteopontin in colitis-associated carcinoma |
| Creators Name: | Manna, S., Sehn, M., Cardoso da Silva, D., Wiese, J.J., Heldt, C., Plumbom, I., Conrad, T., Husemann, C.C., Kleo, K., Derêzanin, L., Dony, V., Farahani, S.K., Weiss, F., Branchi, F., Kühl, A.A., Schallenberg, S., Weiner, J., Elezkurtaj, S., Weixler, B., Gröne, J., Siegmund, B., Hummel, M. and Schumann, M. |
| Abstract: | Patients with ulcerative colitis (UC) and Crohn’s disease (CD) face a lifelong risk of developing colitisassociated carcinoma (CAC). Current insights into CAC development originate from murine CAC models, while human CAC studies primarily focus on mutational analysis of patient samples. Although the mutational landscape reveals distinct patterns and frequencies compared to colorectal cancer, it falls short in elucidating the inflammatory mechanisms of CAC development. Consequently, we adopted a multi-omics approach to unravel CAC carcinogenesis from an immunological perspective. Our data revealed a robust upregulation of SPP1 gene in CAC at both RNA and protein levels, expressed by CD68+ macrophages. In vitro OPN stimulation demonstrated no direct effect on intestinal epithelial organoids. However, the mutually exclusive spatial location of SPP1/OPN+ macrophages and CD8+ T cells suggests a crucial indirect role of SPP1/OPN in mediating an immunosuppressive tumour microenvironment. |
| Source: | bioRxiv |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Article Number: | 2023.12.15.571952 |
| Date: | 16 December 2023 |
| Official Publication: | https://doi.org/10.1101/2023.12.15.571952 |
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