Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Predicting disease severity in multiple sclerosis using multimodal data and machine learning

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[thumbnail of Supporting Information] Other (Supporting Information)
61kB

Item Type:Article
Title:Predicting disease severity in multiple sclerosis using multimodal data and machine learning
Creators Name:Andorra, M., Freire, A., Zubizarreta, I., de Rosbo, N.K., Bos, S.D., Rinas, M., Høgestøl, E.A., de Rodez Benavent, S.A., Berge, T., Brune-Ingebretse, S., Ivaldi, F., Cellerino, M., Pardini, M., Vila, G., Pulido-Valdeolivas, I., Martinez-Lapiscina, E.H., Llufriu, S., Saiz, A., Blanco, Y., Martinez-Heras, E., Solana, E., Bäcker-Koduah, P., Behrens, J., Kuchling, J., Asseyer, S., Scheel, M., Chien, C., Zimmermann, H., Motamedi, S., Kauer-Bonin, J., Brandt, A., Saez-Rodriguez, J., Alexopoulos, L.G., Paul, F., Harbo, H.F., Shams, H., Oksenberg, J., Uccelli, A., Baeza-Yates, R. and Villoslada, P.
Abstract:BACKGROUND: Multiple sclerosis patients would benefit from machine learning algorithms that integrates clinical, imaging and multimodal biomarkers to define the risk of disease activity. METHODS: We have analysed a prospective multi-centric cohort of 322 MS patients and 98 healthy controls from four MS centres, collecting disability scales at baseline and 2 years later. Imaging data included brain MRI and optical coherence tomography, and omics included genotyping, cytomics and phosphoproteomic data from peripheral blood mononuclear cells. Predictors of clinical outcomes were searched using Random Forest algorithms. Assessment of the algorithm performance was conducted in an independent prospective cohort of 271 MS patients from a single centre. RESULTS: We found algorithms for predicting confirmed disability accumulation for the different scales, no evidence of disease activity (NEDA), onset of immunotherapy and the escalation from low- to high-efficacy therapy with intermediate to high-accuracy. This accuracy was achieved for most of the predictors using clinical data alone or in combination with imaging data. Still, in some cases, the addition of omics data slightly increased algorithm performance. Accuracies were comparable in both cohorts. CONCLUSION: Combining clinical, imaging and omics data with machine learning helps identify MS patients at risk of disability worsening.
Keywords:Multiple Sclerosis, Omics, Imaging, Machine Learning, Precision Medicine
Source:Journal of Neurology
ISSN:0340-5354
Publisher:Springer
Volume:271
Number:3
Page Range:1133-1149
Date:March 2024
Official Publication:https://doi.org/10.1007/s00415-023-12132-z
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library