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Mechanisms of resistance to small molecules in acute myeloid leukemia

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Item Type:Review
Title:Mechanisms of resistance to small molecules in acute myeloid leukemia
Creators Name:Lang, T.J.L., Damm, F., Bullinger, L. and Frick, M.
Abstract:In recent years, great progress has been made in the therapy of AML by targeting cellular processes associated with specific molecular features of the disease. Various small molecules inhibiting FLT3, IDH1/IDH2, and BCL2 have already gained approval from the respective authorities and are essential parts of personalized therapeutic regimens in modern therapy of AML. Unfortunately, primary and secondary resistance to these inhibitors is a frequent problem. Here, we comprehensively review the current state of knowledge regarding molecular processes involved in primary and secondary resistance to these agents, covering both genetic and nongenetic mechanisms. In addition, we introduce concepts and strategies for how these resistance mechanisms might be overcome.
Keywords:AML, Small Molecule, Gene Mutations, Resistance, FLT3, IDH1/IDH2, BCL2, Venetoclax, Targeted Therapy, Precision Medicine
Source:Cancers
ISSN:2072-6694
Publisher:MDPI
Volume:15
Number:18
Page Range:4573
Date:15 September 2023
Official Publication:https://doi.org/10.3390/cancers15184573
PubMed:View item in PubMed

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