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Similar neural pathways link psychological stress and brain-age in health and multiple sclerosis

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Item Type:Article
Title:Similar neural pathways link psychological stress and brain-age in health and multiple sclerosis
Creators Name:Schulz, M.A., Hetzer, S., Eitel, F., Asseyer, S., Meyer-Arndt, L., Schmitz-Hübsch, T., Bellmann-Strobl, J., Cole, J.H., Gold, S.M., Paul, F., Ritter, K. and Weygandt, M.
Abstract:Clinical and neuroscientific studies suggest a link between psychological stress and reduced brain health in health and neurological disease but it is unclear whether mediating pathways are similar. Consequently, we applied an arterial-spin-labeling MRI stress task in 42 healthy persons and 56 with multiple sclerosis, and investigated regional neural stress responses, associations between functional connectivity of stress-responsive regions and the brain-age prediction error, a highly sensitive machine learning brain health biomarker, and regional brain-age constituents in both groups. Stress responsivity did not differ between groups. Although elevated brain-age prediction errors indicated worse brain health in patients, anterior insula–occipital cortex (healthy persons: occipital pole; patients: fusiform gyrus) functional connectivity correlated with brain-age prediction errors in both groups. Finally, also gray matter contributed similarly to regional brain-age across groups. These findings might suggest a common stress–brain health pathway whose impact is amplified in multiple sclerosis by disease-specific vulnerability factors.
Source:iScience
ISSN:2589-0042
Publisher:Cell Press
Volume:26
Number:9
Page Range:107679
Date:15 September 2023
Official Publication:https://doi.org/10.1016/j.isci.2023.107679
PubMed:View item in PubMed

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