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Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes

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Item Type:Article
Title:Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes
Creators Name:Schindler, M., Osterwalder, M., Harabula, I., Wittler, L., Tzika, A.C., Dechmann, D.K.N., Vingron, M., Visel, A., Haas, S. and Real, F.M.
Abstract:Changes in gene expression represent an important source of phenotypic innovation. Yet, how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing integrative analyses of epigenetic and transcriptional data in mole and mouse, we identified the co-option of SALL1 expression in mole ovotestes formation. Chromosome conformation capture analyses highlight a striking conservation of the 3D organization at the SALL1 locus, but an evolutionary divergence of enhancer activity. Interspecies reporter assays support the capability of mole-specific enhancers to activate transcription in urogenital tissues. Through overexpression experiments in transgenic mice, we further demonstrate the capability of SALL1 to induce kidney-related gene programs, which are a signature of mole ovotestes. Our results highlight the co-option of gene expression, through changes in enhancer activity, as a plausible mechanism for the evolution of traits.
Keywords:Talpa occidentalis, Atelerix albiventris, Sorex araneus, Animals, Mice
Source:Development
ISSN:0950-1991
Publisher:Company of Biologists
Volume:150
Number:17
Page Range:dev201562
Date:1 September 2023
Official Publication:https://doi.org/10.1242/dev.201562
PubMed:View item in PubMed

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