Genome architecture mapping detects transcriptionally active, multiway chromatin contacts

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Item Type:	Editorial
Title:	Genome architecture mapping detects transcriptionally active, multiway chromatin contacts
Creators Name:	Thieme, C.J. and Pombo, A.
Abstract:	Genome architecture mapping (GAM) enables understanding of 3D genome structure in the nucleus. We directly compared multiplex-GAM and Hi-C data and found that local chromatin interactions were generally detected by both methods, but active genomic regions rich in enhancers that established higher-order contacts were preferentially detected by GAM.
Keywords:	Chromatin, Chromosome Mapping, Chromosomes
Source:	Nature Methods
ISSN:	1548-7091
Publisher:	Nature Publishing Group
Volume:	20
Number:	7
Page Range:	993-994
Date:	July 2023
Official Publication:	https://doi.org/10.1038/s41592-023-01905-z
PubMed:	View item in PubMed

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