Morphine metabolism in human skin microsomes

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Item Type:	Article
Title:	Morphine metabolism in human skin microsomes
Creators Name:	Heilmann, S., Küchler, S. and Schäfer-Korting, M.
Abstract:	For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin. However, for topical administration it is important to know whether the substance is biotransformed in the skin as this can eventually reduce the concentration of the active agent considerably. We use skin microsomes to elucidate the impact of skin metabolism on the activity of topically applied morphine. We are able to demonstrate that morphine is only glucuronidated in traces, indicating that the biotransformation in the skin can be neglected when morphine is applied topically. Hence, there is no need to take biotransformation into account when setting up the treatment regimen.
Keywords:	Morphine, UGT2B7, Morphine Glucuronidation, Skin Metabolism, Human Skin Microsomes
Source:	Skin Pharmacology and Physiology
ISSN:	1660-5527
Publisher:	Karger
Volume:	25
Number:	6
Page Range:	319-22
Date:	October 2012
Official Publication:	https://doi.org/10.1159/000342067
PubMed:	View item in PubMed

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