Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology

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Item Type:	Article
Title:	Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology
Creators Name:	Abdelhak, A., Solomon, I., Montes, S.C., Saias, A., Cordano, C., Asken, B., Fonseca, C., Oertel, F.C., Arfanakis, K., Staffaroni, A.M., Kramer, J.H., Geschwind, M., Miller, B.L., Elahi, F.M. and Green, A.J.
Abstract:	INTRODUCTION: Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non-invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. METHODS: Intensity-based retinal arteriolar visualization in optical coherence tomography (I-bRAVO) was applied to evaluate mean wall thickness (MWT) and wall-to-lumen ratio (WLR) in 250 subjects with sporadic and genetic cerebral small vessel disease (CSVD), non-vascular neurodegenerative diseases (NVND), and healthy controls (HC) in association with imaging and cognitive markers. RESULTS: MWT and WLR were higher in CSVD, associated with severity of vascular white matter lesions, and correlated with magnetic resonance imaging-based intracranial arteriolosclerosis score. WLR correlated with gray and white matter volume and differentiated asymptomatic sporadic CSVD from HC (area under the curve = 0.82). DISCUSSION: I-bRAVO is a rapid, non-invasive tool. MWT and WLR were associated with imaging markers of CSVD and could contribute to early identification of sporadic CSVD.
Keywords:	Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Cerebral Small Vessel Disease, Retinal Vessels, Vascular Dementia, White Matter Disease
Source:	Alzheimer's & Dementia: Diagnosis Assessment & Disease Monitoring
ISSN:	2352-8729
Publisher:	Elsevier
Volume:	14
Number:	1
Page Range:	e12338
Date:	2022
Official Publication:	https://doi.org/10.1002/dad2.12338
PubMed:	View item in PubMed

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