Genetic models

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Item Type:	Book Section
Title:	Genetic models
Creators Name:	Alenina, N. and Bader, M.
Abstract:	Genetically altered rat and mouse models have been instrumental in the functional analysis of genes in a physiological context. In particular, studies on the renin-angiotensin system (RAS) have profited from this technology in the past. In this review, we summarize the existing animal models for the protective axis of the RAS consisting of angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7)(Ang-(1-7), and its receptor Mas. With the help of models with altered expression of the components of this axis in the brain and cardiovascular organs, its physiological and pathophysiological functions have been elucidated. Thus, novel opportunities for therapeutic interventions in cardiovascular diseases were revealed targeting ACE2 or Mas.
Keywords:	Angiotensin (1-7), ACE2, Mas, Transgenic Mice, Transgenic Rats, Knockout, Animals, Mice, Rats
Source:	Angiotensin-(1-7)
Title of Book:	Angiotensin-(1-7) : a comprehensive review
ISBN:	978-3-030-22695-4
Publisher:	Springer
Page Range:	35-51
Date:	2019
Official Publication:	https://doi.org/10.1007/978-3-030-22696-1_3

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