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| Item Type: | Article |
|---|---|
| Title: | Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points |
| Creators Name: | Huemer, M.T., Kluttig, A., Fischer, B., Ahrens, W., Castell, S., Ebert, N., Gastell, S., Jöckel, K.H., Kaaks, R., Karch, A., Keil, T., Kemmling, Y., Krist, L., Leitzmann, M., Lieb, W., Meinke-Franze, C., Michels, K.B., Mikolajczyk, R., Moreno Velásquez, I., Pischon, T., Schipf, S., Schmidt, B., Schöttker, B., Schulze, M.B., Stocker, H., Teismann, H., Wirkner, K., Drey, M., Peters, A. and Thorand, B. |
| Abstract: | BACKGROUND: The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies. OBJECTIVE: Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample. METHODS: We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality. RESULTS: Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality. CONCLUSIONS: Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed. |
| Keywords: | Grip Strength, Probable Sarcopenia, European Working Group on Sarcopenia in Older People (EWGSOP), Mortality, Cut-Off Points |
| Source: | Age and Ageing |
| ISSN: | 1468-2834 |
| Publisher: | Oxford University Press |
| Volume: | 52 |
| Number: | 1 |
| Page Range: | afac324 |
| Date: | January 2023 |
| Official Publication: | https://doi.org/10.1093/ageing/afac324 |
| PubMed: | View item in PubMed |
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