Single-cell multi-omics and lineage tracing to dissect cell fate decision-making

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Item Type:	Review
Title:	Single-cell multi-omics and lineage tracing to dissect cell fate decision-making
Creators Name:	Haghverdi, L. and Ludwig, L.S.
Abstract:	The concept of cell fate relates to the future identity of a cell, and its daughters, which is obtained via cell differentiation and division. Understanding, predicting, and manipulating cell fate has been a long-sought goal of developmental and regenerative biology. Recent insights obtained from single-cell genomic and integrative lineage-tracing approaches have further aided to identify molecular features predictive of cell fate. In this perspective, we discuss these approaches with a focus on theoretical concepts and future directions of the field to dissect molecular mechanisms underlying cell fate.
Keywords:	Cell Fate Decision, Mathematical and Computational Models, Multi-Omics, Clonal Tracking, Haematopoiesis, Embryogenesis
Source:	Stem Cell Reports
ISSN:	2213-6711
Publisher:	Cell Press / Elsevier
Volume:	18
Number:	1
Page Range:	13-25
Date:	10 January 2023
Official Publication:	https://doi.org/10.1016/j.stemcr.2022.12.003
PubMed:	View item in PubMed

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