Autophagy in T and B lymphocytes

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Item Type:	Article
Title:	Autophagy in T and B lymphocytes
Creators Name:	Clarke, A.J. and Simon, A.K.
Abstract:	Autophagy is now understood to have an active role in the adaptive immune system, participating in lymphocyte development, differentiation, and memory. In T cells, it is activated during thymocyte development, and following receptor ligation, and is also critical for T cell memory. In B cells, there is again activation of autophagy during development, and whilst it is dispensable for maintenance of the peripheral B2 cell pool, it is required for normal formation of B1 B cells. Autophagy is strongly active in plasma cells, which appear to use it as a mechanism for survival of the metabolic stress associated with immunoglobulin production. Finally, as with T cells, autophagy is necessary for memory B cell maintenance.
Keywords:	Autophagy Gene, Common Lymphoid Progenitor, Teff Cell, Thymocyte Development, Systemic Lupus Erythematosus
Source:	Autophagy Networks in Inflammation
Series Name:	Progress in Inflammation Research
Title of Book:	Autophagy Networks in Inflammation
ISSN:	1422-7746
ISBN:	9783319300771
Publisher:	Springer Nature
Page Range:	171-184
Number of Pages:	403
Date:	25 August 2016
Official Publication:	https://doi.org/10.1007/978-3-319-30079-5_9

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