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| Item Type: | Article |
|---|---|
| Title: | Olfactory dysfunction in patients with neuromyelitis optica |
| Creators Name: | Schmidt, F., Göktas, O., Jarius, S., Wildemann, B., Ruprecht, K., Paul, F. and Harms, L. |
| Abstract: | BACKGROUND: Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory function (OF) in patients with neuromyelitis optica (NMO) versus healthy controls (HC). METHODS: Psychophysical testing of the orthonasal OF was performed using the Threshold-Discrimination-Identification test (TDI), measuring different qualities of olfaction, in 10 unselected NMO patients and 10 HC. RESULTS: Five of 10 NMO patients (50%) showed hyposmia, while all 10 HC were normosmic. Moreover, NMO patients had significantly lower mean TDI-scores compared to HC, based on a poorer performance in both the Discrimination and the Identification subtests. CONCLUSIONS: Our results suggest that hyposmia might be part of the expanding clinical spectrum of NMO. |
| Source: | Multiple Sclerosis International |
| ISSN: | 2090-2654 |
| Publisher: | Hindawi |
| Volume: | 2013 |
| Page Range: | 654501 |
| Date: | 25 September 2013 |
| Official Publication: | https://doi.org/10.1155/2013/654501 |
| PubMed: | View item in PubMed |
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