Olfactory dysfunction in patients with neuromyelitis optica

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Item Type:	Article
Title:	Olfactory dysfunction in patients with neuromyelitis optica
Creators Name:	Schmidt, F., Göktas, O., Jarius, S., Wildemann, B., Ruprecht, K., Paul, F. and Harms, L.
Abstract:	BACKGROUND: Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory function (OF) in patients with neuromyelitis optica (NMO) versus healthy controls (HC). METHODS: Psychophysical testing of the orthonasal OF was performed using the Threshold-Discrimination-Identification test (TDI), measuring different qualities of olfaction, in 10 unselected NMO patients and 10 HC. RESULTS: Five of 10 NMO patients (50%) showed hyposmia, while all 10 HC were normosmic. Moreover, NMO patients had significantly lower mean TDI-scores compared to HC, based on a poorer performance in both the Discrimination and the Identification subtests. CONCLUSIONS: Our results suggest that hyposmia might be part of the expanding clinical spectrum of NMO.
Source:	Multiple Sclerosis International
ISSN:	2090-2654
Publisher:	Hindawi
Volume:	2013
Page Range:	654501
Date:	25 September 2013
Official Publication:	https://doi.org/10.1155/2013/654501
PubMed:	View item in PubMed

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