DNA methylation abnormalities in hematopoietic disorders: biological significance and methodological approaches

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Item Type:	Book Section
Title:	DNA methylation abnormalities in hematopoietic disorders: biological significance and methodological approaches
Creators Name:	Claus, R., Schmutz, M., Greve, G. and Bullinger, L.
Abstract:	Over the past years, the role of genetic events in hematopoietic malignancies has been studied extensively, and many molecular defects and their contribution to leukemogenesis could be unraveled. However, the understanding of epigenetic alterations is not as advanced, but it is currently gaining strong momentum as epigenetics are likely to play a major role in leukemogenesis. DNA methylation is an important epigenetic mechanism regulating gene transcription and occurring in both normal and malignant hematopoiesis. Whereas the balance and coordination of this regulatory process is fundamentally required in normal blood cell development, it is often perturbed in hematopoietic malignancies. The first part of this chapter discusses mechanisms and targets of aberrant DNA methylation as well as their biological significance in hematopoietic disorders. In addition, the second part provides a brief overview of commonly used techniques for site-specific and global DNA methylation analyses.
Title of Book:	Epigenetic Therapy of Cancer: Preclinical Models and Treatment Approaches
ISBN:	9783642384035
Publisher:	Springer
Page Range:	107-120
Number of Pages:	14
Date:	2014
Official Publication:	https://doi.org/10.1007/978-3-642-38404-2_5

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