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| Item Type: | Article |
|---|---|
| Title: | MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development |
| Creators Name: | Schneider, E., Staffas, A., Röhner, L., Krowiorz, K., Heuser, M., Döhner, K., Bullinger, L., Döhner, H., Fogelstrand, L., Rouhi, A., Kuchenbauer, F. and Palmqvist, L. |
| Abstract: | MicroRNA-155 (miR-155) is an oncogenic miRNA upregulated in various tumor types and leukemias and has been suggested as a potential drug target. Based on our previous work detecting high miR-155 levels in response to Meis1 overexpression in a murine Hox leukemia model, we show here the relationship among HOXA9, MEIS1, and miR-155 levels in MLL-translocated acute myeloid leukemia (AML) patients. Using mouse bone marrow cells transformed by MLL-fusion genes expressing graduated levels of Meis1, we show a positive correlation between miR-155 and Meis1. However, using a miR-155-knockout mouse model, we show that the absence and the depletion of miR-155 have no effect on leukemia formation or progression. We also show for the first time that miR-155 levels are correlated with MLL translocations, but that miR-155 expression is dispensable for the formation of AML and has no effect on leukemia progression. |
| Keywords: | Acute Myeloid Leukemia, Animal Disease Models, Bone Marrow Cells, Bone Marrow Transplantation, Fusion Oncogene Proteins, Gene Knockout Techniques, Gene Rearrangement, Homeodomain Proteins, Leukemic Gene Expression Regulation, MicroRNAs, Myeloid Ecotropic Viral Integration Site 1 Protein, Myeloid-Lymphoid Leukemia Protein, Neoplasm Proteins, Tumor Cell Line, Animals, Mice |
| Source: | Experimental Hematology |
| ISSN: | 0301-472X |
| Publisher: | Elsevier |
| Volume: | 44 |
| Number: | 12 |
| Page Range: | 1166-1171 |
| Date: | December 2016 |
| Official Publication: | https://doi.org/10.1016/j.exphem.2016.08.012 |
| PubMed: | View item in PubMed |
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