![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB |
![[thumbnail of Supporting Information]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supporting Information)
566kB |
| Item Type: | Article |
|---|---|
| Title: | Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia |
| Creators Name: | Schneider, E., Staffas, A., Röhner, L., Malmberg, E.D., Ashouri, A., Krowiorz, K., Pochert, N., Miller, C., Wei, S.Y., Arabanian, L., Buske, C., Döhner, H., Bullinger, L., Fogelstrand, L., Heuser, M., Döhner, K., Xiang, P., Ruschmann, J., Petriv, O.I., Heravi-Moussavi, A., Hansen, C.L., Hirst, M., Humphries, R.K., Rouhi, A., Palmqvist, L. and Kuchenbauer, F. |
| Abstract: | Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR-155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells However, in the absence or following the removal of miR-155, leukemia onset and progression were unaffected. Although miR-155 accelerated growth and homing in addition to impairing differentiation, our data underscore the pathophysiological relevance of miR-155 as an accelerator rather than a driver of leukemogenesis. This further highlights the complexity of the oncogenic program of Meis1 to compensate for the loss of a potent oncogene such as miR-155. These findings are highly relevant to current and developing approaches for targeting miR-155 in acute myeloid leukemia. |
| Keywords: | Carcinogenesis, Leukemic Gene Expression Regulation, Homeodomain Proteins, Acute Myeloid Leukemia, MicroRNAs, Myeloid Ecotropic Viral Integration Site 1 Protein / Pharmacology, Animals, Mice |
| Source: | Haematologica |
| ISSN: | 0390-6078 |
| Publisher: | Ferrata Storti Foundation |
| Volume: | 103 |
| Number: | 2 |
| Page Range: | 246-255 |
| Date: | February 2018 |
| Official Publication: | https://doi.org/10.3324/haematol.2017.177485 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
