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| Item Type: | Article |
|---|---|
| Title: | Vitamin D status and risk of all-cause and cause-specific mortality in osteoarthritis patients: results from NHANES III and NHANES 2001-2018 |
| Creators Name: | Wang, J., Fan, J., Yang, Y., Moazzen, S., Chen, D., Sun, L., He, F. and Li, Y. |
| Abstract: | OBJECTIVES: The role of Vitamin D (VD) in calcium balance and bone health makes VD a vital factor in osteoarthritis (OA). Studies that have evaluated the effect of VD on OA patients have mainly been performed on a short-term basis. In this analysis, we aimed to evaluate whether VD was associated with mortality, a long-term outcome, in OA patients. METHODS: Participants with self-reported OA from NHANES III and NHANES 2001-2018 were included. Associations of 25(OH)D concentrations with mortality risk were assessed continuously using restricted cubic splines and by categories (i.e., <25.0, 25.0-49.9, 50.0-74.9, and ≥75.0 nmol/L) using the Cox regression model. Sensitivity and stratified analyses were performed to evaluate the robustness of the results. RESULTS: A total of 4570 patients were included, of which 1388 died by 31 December 2019. An L-shaped association was observed between 25(OH)D concentrations and all-cause mortality, whereas an inverse association was found for cardiovascular disease (CVD) mortality. The adjusted hazard ratios (95% confidence intervals) across four categories were 1.00 (reference), 0.49 (0.31, 0.75), 0.45 (0.29, 0.68), and 0.43 (0.27, 0.69) for all-cause mortality and 1.00 (reference), 0.28 (0.14, 0.59), 0.25 (0.12, 0.51), and 0.24 (0.11, 0.49) for CVD-specific mortality; no significant associations were found for cancer-specific mortality. Similar results were observed when stratified and sensitivity analyses were performed. CONCLUSIONS: Compared with patients with insufficient or deficient serum 25(OH)D, those with sufficient 25(OH)D concentrations had a lower risk of all-cause and CVD mortality, supporting a beneficial role of VD on a long-term basis. |
| Keywords: | Vitamin D, Osteoarthritis, Mortality, NHANES |
| Source: | Nutrients |
| ISSN: | 2072-6643 |
| Publisher: | MDPI |
| Volume: | 14 |
| Number: | 21 |
| Page Range: | 4629 |
| Date: | 3 November 2022 |
| Official Publication: | https://doi.org/10.3390/nu14214629 |
| PubMed: | View item in PubMed |
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