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| Item Type: | Article |
|---|---|
| Title: | Lifetime and current depression in the German National Cohort (NAKO) |
| Creators Name: | Streit, F., Zillich, L., Frank, J., Kleineidam, L., Wagner, M., Baune, B.T., Klinger-König, J., Grabe, H.J., Pabst, A., Riedel-Heller, S.G., Schmiedek, F., Schmidt, B., Erhardt, A., Deckert, J., Rietschel, M. and Berger, K. |
| Abstract: | OBJECTIVES: The present study introduces the assessment of depression and depressive symptoms in the German National Cohort (NAKO), a population-based mega cohort. Distribution of core measures, and associations with sociodemographic factors are examined. METHODS: The current analysis includes data from the first 101,667 participants (NAKO data freeze 100,000). Depression and depressive symptoms were assessed using a modified version of the depression section of the Mini-International Neuropsychiatric Interview (MINI), self-reported physician's diagnosis of depression, and the depression scale of the Patient Health Questionnaire (PHQ-9). RESULTS: A lifetime physician's diagnosis of depression was reported by 15.0% of participants. Of those, 47.6% reported having received treatment for depression within the last 12 months. Of the subset of 26,342 participants undergoing the full depression section of the modified MINI, 15.9% were classified by the MINI with a lifetime depressive episode. Based on the PHQ-9, 5.8% of the participants were classified as currently having a major or other depression by the diagnostic algorithm, and 7.8% according to the dimensional assessment (score = 10). Increased frequency of depression measures and higher depression scores were observed in women and participants with lower education level or a family history of depression. CONCLUSIONS: The observed distributions of all depression measures and their associations with sociodemographic variables are consistent with the literature on depression. The NAKO represents a valuable epidemiologic resource to investigate depression, and the range of measures for lifetime and current depression allows users to select the most suitable instrument for their specific research question. |
| Keywords: | MINI Interview, PHQ-9, PHQ-Stress, Depressive Symptoms, Family History of Depression |
| Source: | World Journal of Biological Psychiatry |
| ISSN: | 1562-2975 |
| Publisher: | Informa Healthcare |
| Volume: | 24 |
| Number: | 10 |
| Page Range: | 865-880 |
| Date: | 17 February 2022 |
| Additional Information: | Insa Feinkohl and Tobias Pischon are NAKO Investigator authors. |
| Official Publication: | https://doi.org/10.1080/15622975.2021.2014152 |
| PubMed: | View item in PubMed |
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