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Human stem cell models: lessons for pancreatic development and disease

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Item Type:Review
Title:Human stem cell models: lessons for pancreatic development and disease
Creators Name:Gaertner, B., Carrano, A.C. and Sander, M.
Abstract:A comprehensive understanding of mechanisms that underlie the development and function of human cells requires human cell models. For the pancreatic lineage, protocols have been developed to differentiate human pluripotent stem cells (hPSCs) into pancreatic endocrine and exocrine cells through intermediates resembling in vivo development. In recent years, this differentiation system has been employed to decipher mechanisms of pancreatic development, congenital defects of the pancreas, as well as genetic forms of diabetes and exocrine diseases. In this review, we summarize recent insights gained from studies of pancreatic hPSC models. We discuss how genome-scale analyses of the differentiation system have helped elucidate roles of chromatin state, transcription factors, and noncoding RNAs in pancreatic development and how the analysis of cells with disease-relevant mutations has provided insight into the molecular underpinnings of genetically determined diseases of the pancreas.
Keywords:Embryonic, Pancreatic Development, Stem Cell
Source:Genes & Development
ISSN:0890-9369
Publisher:Cold Spring Harbor Laboratory Press
Volume:33
Number:21-22
Page Range:1475-1490
Date:1 November 2019
Official Publication:https://doi.org/10.1101/gad.331397.119
PubMed:View item in PubMed

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