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| Item Type: | Article |
|---|---|
| Title: | Advances in β cell replacement and regeneration strategies for treating diabetes |
| Creators Name: | Benthuysen, J.R., Carrano, A.C. and Sander, M. |
| Abstract: | In the past decade, new approaches have been explored that are aimed at restoring functional β cell mass as a treatment strategy for diabetes. The two most intensely pursued strategies are β cell replacement through conversion of other cell types and β cell regeneration by enhancement of β cell replication. The approach closest to clinical implementation is the replacement of β cells with human pluripotent stem cell-derived (hPSC-derived) cells, which are currently under investigation in a clinical trial to assess their safety in humans. In addition, there has been success in reprogramming developmentally related cell types into β cells. Reprogramming approaches could find therapeutic applications by inducing β cell conversion in vivo or by reprogramming cells ex vivo followed by implantation. Finally, recent studies have revealed novel pharmacologic targets for stimulating β cell replication. Manipulating these targets or the pathways they regulate could be a strategy for promoting the expansion of residual β cells in diabetic patients. Here, we provide an overview of progress made toward β cell replacement and regeneration and discuss promises and challenges for clinical implementation of these strategies. |
| Keywords: | Cell Proliferation, Cell Transdifferentiation, Cellular Reprogramming, Diabetes Mellitus, Insulin-Secreting Cells, Pluripotent Stem Cells, Regeneration, Animals |
| Source: | Journal of Clinical Investigation |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Volume: | 126 |
| Number: | 10 |
| Page Range: | 3651-3660 |
| Date: | 3 October 2016 |
| Official Publication: | https://doi.org/10.1172/JCI87439 |
| PubMed: | View item in PubMed |
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