Advances in β cell replacement and regeneration strategies for treating diabetes

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Item Type:	Article
Title:	Advances in β cell replacement and regeneration strategies for treating diabetes
Creators Name:	Benthuysen, J.R., Carrano, A.C. and Sander, M.
Abstract:	In the past decade, new approaches have been explored that are aimed at restoring functional β cell mass as a treatment strategy for diabetes. The two most intensely pursued strategies are β cell replacement through conversion of other cell types and β cell regeneration by enhancement of β cell replication. The approach closest to clinical implementation is the replacement of β cells with human pluripotent stem cell-derived (hPSC-derived) cells, which are currently under investigation in a clinical trial to assess their safety in humans. In addition, there has been success in reprogramming developmentally related cell types into β cells. Reprogramming approaches could find therapeutic applications by inducing β cell conversion in vivo or by reprogramming cells ex vivo followed by implantation. Finally, recent studies have revealed novel pharmacologic targets for stimulating β cell replication. Manipulating these targets or the pathways they regulate could be a strategy for promoting the expansion of residual β cells in diabetic patients. Here, we provide an overview of progress made toward β cell replacement and regeneration and discuss promises and challenges for clinical implementation of these strategies.
Keywords:	Cell Proliferation, Cell Transdifferentiation, Cellular Reprogramming, Diabetes Mellitus, Insulin-Secreting Cells, Pluripotent Stem Cells, Regeneration, Animals
Source:	Journal of Clinical Investigation
ISSN:	0021-9738
Publisher:	American Society for Clinical Investigation
Volume:	126
Number:	10
Page Range:	3651-3660
Date:	3 October 2016
Official Publication:	https://doi.org/10.1172/JCI87439
PubMed:	View item in PubMed

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