Macrophages and HIV-1: an unhealthy constellation

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Item Type:	Review
Title:	Macrophages and HIV-1: an unhealthy constellation
Creators Name:	Sattentau, Q.J. and Stevenson, M.
Abstract:	Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.
Keywords:	HIV-1, Macrophage, Reservoir, Pathogenesis
Source:	Cell Host & Microbe
ISSN:	1931-3128
Publisher:	Elsevier / Cell Press
Volume:	19
Number:	3
Page Range:	304-310
Date:	9 March 2016
Additional Information:	Copyright © 2016 Elsevier Inc. All rights reserved.
Official Publication:	https://doi.org/10.1016/j.chom.2016.02.013
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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