The HIV-1-containing macrophage compartment: a perfect cellular niche?

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Item Type:	Review
Title:	The HIV-1-containing macrophage compartment: a perfect cellular niche?
Creators Name:	Tan, J. and Sattentau, Q.J.
Abstract:	Macrophages are a major target of HIV-1 infection and are believed to act as viral reservoirs and mediators of HIV-1-associated neurological damage. These pathological roles may be associated with the ability of the virus to assemble and accumulate in apparently intracellular compartments in macrophages. These so-called virus-containing compartments were initially thought to be late endosomes or multivesicular bodies, but it has since been shown that they are distinct structures that have complex three-dimensional morphology, a unique set of protein markers, and features such as a near-neutral pH and frequent connections to the extracellular milieu. These features appear to protect HIV-1 from hostile elements both within and outside the cell. This review discusses the cellular and molecular characteristics of HIV-1-containing compartments in macrophages and how they offer a safe haven for the virus, with important consequences for pathogenesis.
Keywords:	HIV-1, Macrophage, Virus Containing Compartment, Cell-To-Cell Spread, Immune Evasion
Source:	Trends in Microbiology
ISSN:	0966-842X
Publisher:	Elsevier
Volume:	21
Number:	8
Page Range:	405-412
Date:	8 August 2013
Official Publication:	https://doi.org/10.1016/j.tim.2013.05.001
PubMed:	View item in PubMed

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