![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
| Item Type: | Review |
|---|---|
| Title: | Senescence and cancer - role and therapeutic opportunities |
| Creators Name: | Schmitt, C.A., Wang, B. and Demaria, M. |
| Abstract: | Cellular senescence is a state of stable, terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells into senescence can act as a barrier to tumorigenesis and, thus, could in principle constitute a desired outcome for any anticancer therapy. Paradoxically, studies published in the past decade have demonstrated that, in certain conditions and contexts, malignant and non-malignant cells with lastingly persistent senescence can acquire pro-tumorigenic properties. In this Review, we first discuss the major mechanisms involved in the antitumorigenic functions of senescent cells and then consider the cell-intrinsic and cell-extrinsic factors that participate in their switch towards a tumour-promoting role, providing an overview of major translational and emerging clinical findings. Finally, we comprehensively describe various senolytic and senomorphic therapies and their potential to benefit patients with cancer. |
| Keywords: | Cancer, Cell Biology |
| Source: | Nature Reviews Clinical oncology |
| ISSN: | 1759-4774 |
| Publisher: | Nature Publishing Group |
| Volume: | 19 |
| Number: | 10 |
| Page Range: | 619–636 |
| Date: | October 2022 |
| Additional Information: | Copyright © 2022 Springer Nature Limited. |
| Official Publication: | https://doi.org/10.1038/s41571-022-00668-4 |
| External Fulltext: | View full text on PubMed Central |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
