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| Item Type: | Article |
|---|---|
| Title: | Serum glial fibrillary acidic protein correlates with retinal structural damage in aquaporin-4 antibody positive neuromyelitis optica spectrum disorder |
| Creators Name: | Lin, T.Y., Schindler, P., Grittner, U., Oertel, F.C., Lu, A., Motamedi, S., Yadav, S.K., Duchow, A.S., Jarius, S., Kuhle, J., Benkert, P., Brandt, A.U., Bellmann-Strobl, J., Schmitz-Hübsch, T., Paul, F., Ruprecht, K. and Zimmermann, H.G. |
| Abstract: | BACKGROUND: Aquaporin-4 immunoglobulin-G positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy associated with optic neuritis (ON). Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an oligodendrocytopathy with similar phenotype. Serum glial fibrillary acidic protein (sGFAP), an astrocyte-derived protein, is associated with disease severity in AQP4-IgG+ NMOSD. Serum neurofilament light (sNfL) indicates neuroaxonal damage. The objective was to investigate the association of sGFAP and sNfL with subclinical afferent visual system damage in clinically stable AQP4-IgG+ NMOSD and MOGAD patients. METHODS: In this cross-sectional study, clinically stable patients with AQP4-IgG+ NMOSD (N=33) and MOGAD (N=16), as diseased controls, underwent sGFAP and sNfL measurements by single molecule array, retinal optical coherence tomography and visually evoked potentials. RESULTS: Higher sGFAP concentrations were associated with thinner ganglion cell-inner plexiform layer (ß(95% confidence interval (CI)) = -0.75(-1.23 to -0.27), p=0.007) and shallower fovea (average pit depth: ß(95%CI) = -0.59(-0.63 to -0.55), p=0.020) in NMOSD non-ON eyes. Participants with pathological P100 latency had higher sGFAP (median [interquartile range]: 131.32 [81.10–179.34] vs. 89.50 [53.46–121.91]pg/ml, p=0.024). In MOGAD, sGFAP was not associated with retinal structural or visual functional measures. CONCLUSIONS: The association of sGFAP with structural and functional markers of afferent visual system damage in absence of ON suggests that sGFAP may be a sensitive biomarker for chronic disease severity in clinically stable AQP4-IgG+ NMOSD. |
| Keywords: | Aquaporin 4, Autoantibodies, Biomarkers, Cross-Sectional Studies, Glial Fibrillary Acidic Protein, Immunoglobulin G, Intermediate Filaments, Neuromyelitis Optica, Optic Neuritis, Retinal Diseases |
| Source: | Multiple Sclerosis and Related Disorders |
| ISSN: | 2211-0348 |
| Publisher: | Elsevier |
| Volume: | 67 |
| Page Range: | 104100 |
| Date: | November 2022 |
| Additional Information: | Copyright © 2022. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. |
| Official Publication: | https://doi.org/10.1016/j.msard.2022.104100 |
| PubMed: | View item in PubMed |
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