Neuroprotection by T-cells depends on their subtype and activation state

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Item Type:	Article
Title:	Neuroprotection by T-cells depends on their subtype and activation state
Creators Name:	Wolf, S.A., Fisher, J., Bechmann, I., Steiner, B., Kwidzinski, E. and Nitsch, R.
Abstract:	This study analyzes how the antigen specificity, the subtype, and the activation state of T cells modulate their recently discovered neuroprotective potential. We assessed the prevention from neuronal damage in organotypic entorhinal-hippocampal slice cultures after co-culture with Th1 and Th2 cells either specific for myelin basic protein (MBP) or ovalbumin (OVA). We found that MBP-specific Th2 cells were the most effective in preventing central nervous system (CNS) tissue from secondary injury. This neuroprotective T cell effect appears to be mediated by soluble factors. After stimulation with phorbol myristate acetate and ionomycin, all T cells were most effective in preventing neuronal death. Our data show that the T cell subtype and activation state are important features in determining the neuroprotective potential of these cells.
Keywords:	Brain Trauma, Hippocampus, MBP, Neuroprotection, Organotypic Slice Culture, T Cells, Animals, Mice
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	133
Number:	1-2
Page Range:	72-80
Date:	December 2002
Official Publication:	https://doi.org/10.1016/s0165-5728(02)00367-3
PubMed:	View item in PubMed

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