Th2 cells support intrinsic anti-inflammatory properties of the brain

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Item Type:	Article
Title:	Th2 cells support intrinsic anti-inflammatory properties of the brain
Creators Name:	Gimsa, U., Wolf, S.A., Haas, D.., Bechmann, I. and Nitsch, R.
Abstract:	In experimental autoimmune encephalomyelitis (EAE), Th1 cells are responsible for disease induction while Th2 cells can be protective. To address the mechanisms of this differential behavior, we utilized organotypic murine entorhinal-hippocampal slice cultures to analyze interactions between myelin basic protein-specific Th1 and Th2 cells with microglial cells. While both Th1 and Th2 cells induced CD40 expression, only Th1 cells induced intercellular adhesion molecule-1 (ICAM-1) expression on microglia. Moreover, Th2 cells prevented or even reversed Th1-induced ICAM-1 upregulation. Evidently, Th2 cells could diminish Th1-induced inflammatory reactions and actively support the resting state of microglia, which could be one mechanism of Th2-mediated remission of neuroinflammation during EAE.
Keywords:	Brain Slice Cultures, Costimulation, Microglial Activation, MBP, Experimental Autoimmune Encephalomyelitis, Animals, Mice
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	119
Number:	1
Page Range:	73-80
Date:	3 September 2001
Official Publication:	https://doi.org/10.1016/s0165-5728(01)00343-5
PubMed:	View item in PubMed

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