Subventricular zone microglia transcriptional networks

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Item Type:	Article
Title:	Subventricular zone microglia transcriptional networks
Creators Name:	Starossom, S.C., Imitola, J., Wang, Y., Cao, L. and Khoury, S.J.
Abstract:	Microglia play an important role in inflammatory diseases of the central nervous system. There is evidence of microglial diversity with distinct phenotypes exhibiting either neuroprotection and repair or neurotoxicity. However the precise molecular mechanisms underlying this diversity are still unknown. Using a model of experimental autoimmune encephalomyelitis (EAE) we performed transcriptional profiling of isolated subventricular zone microglia from the acute and chronic disease phases of EAE. We found that microglia exhibit disease phase specific gene expression signatures, that correspond to unique gene ontology functions and genomic networks. Our data demonstrate for the first time, distinct transcriptional networks of microglia activation in vivo, that suggests a role as mediators of injury or repair.
Keywords:	EAE, MS, Microglia, SVZ, Neural Stem Cells, Microarray, Animals, Mice
Source:	Brain Behavior and Immunity
ISSN:	0889-1591
Publisher:	Elsevier / Academic Press
Volume:	25
Number:	5
Page Range:	991-999
Date:	July 2011
Additional Information:	Copyright © 2010 Elsevier Inc. All rights reserved.
Official Publication:	https://doi.org/10.1016/j.bbi.2010.11.002
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