The hypothalamic-pituitary axis: co-development of two organs

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Item Type:	Review
Title:	The hypothalamic-pituitary axis: co-development of two organs
Creators Name:	Treier, M. and Rosenfeld, M.G.
Abstract:	Development of the anterior pituitary gland ultimately leads to the appearance of five distinct cell types that are defined by the trophic hormones which they produce, providing an instructive model system for elucidating the molecular mechanisms that underlie the determination of distinct cell phenotypes within an organ from a common precursor lineage. The recent identification of several homeodomain transcription factors expressed specifically in the anterior pituitary gland has revealed a transcriptional cascade orchestrating a developmental program that leads to the determination of the five mature cell types. Recent data from gene-targeting experiments in mice further imply that the execution of this program is dependent on inductive signals originating in the floor of the diencephalon.
Keywords:	Cell Differentiation, Developmental Gene Expression Regulation, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Animals, Mice
Source:	Current Opinion in Cell Biology
ISSN:	0955-0674
Publisher:	Current Biology Ltd
Volume:	8
Number:	6
Page Range:	833-843
Date:	December 1996
Official Publication:	https://doi.org/10.1016/S0955-0674(96)80085-8
PubMed:	View item in PubMed

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