Intramolecular signal transduction in c-Jun

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Item Type:	Article
Title:	Intramolecular signal transduction in c-Jun
Creators Name:	Papavassiliou, A.G., Treier, M. and Bohmann, D.
Abstract:	The DNA‐binding activity of c‐Jun is determined by the phosphorylation state of a cluster of threonine and serine residues located near its COOH‐terminus. We have analyzed the events that lead to c‐Jun activation via dephosphorylation of these sites in response to phorbol esters. Our results indicate that COOH‐terminal dephosphorylation is an indirect consequence of a separate phosphorylation event targeted to the NH2‐terminus of c‐Jun. Thus, the activation of c‐Jun DNA‐binding potential, caused by COOH‐terminal dephosphorylation, may not require the regulation of the kinase/phosphatase system that brings about this change, but rather an alteration in the accessibility of the COOH‐terminal phosphoacceptor sites of c‐Jun.
Keywords:	C-Jun, Protein Phosphorylation, Signal Transduction, Transcription Factor AP-1
Source:	EMBO Journal
ISSN:	0261-4189
Publisher:	Oxford University Press
Volume:	14
Number:	9
Page Range:	2014-2019
Date:	1 May 1995
Additional Information:	Copyright © 1995 Oxford University Press / European Molecular Biology Organization.
Official Publication:	https://doi.org/10.1002/j.1460-2075.1995.tb07193.x
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