Differential regulation of c-Jun and JunD by ubiquitin-dependent protein degradation

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Item Type:	Article
Title:	Differential regulation of c-Jun and JunD by ubiquitin-dependent protein degradation
Creators Name:	Musti, A.M., Treier, M., Peverali, F.A. and Bohmann, D.
Abstract:	c-Jun and JunD are two closely related members of the Jun family of transcription factors which markedly differ in their biological functions. Whereas c-Jun behaves as a positive regulator of cell growth and may cause cell transformation when overexpressed, JunD antagonizes both of these effects. To better understand how the activities of c-Jun and JunD are controlled, we investigated how their stabilities within the cell are determined. We show that, in contrast to c-Jun which is degraded following multi ubiquitination, JunD is not efficiently ubiquitinated and exhibits a correspondingly longer half-life. Mutational analysis reveals that the determinant for the difference in ubiquitination resides in the NH2-terminal regions of the proteins which in c-Jun contains the delta-domain.
Keywords:	Protein Degradation, Transcription Factor, Ubiquitin, C-Jun, JunD, Animals, Mice
Source:	Biological Chemistry
ISSN:	1431-6730
Publisher:	Walter de Gruyter & Co
Volume:	377
Number:	10
Page Range:	619-624
Date:	October 1996
Official Publication:	https://doi.org/10.1515/bchm3.1996.377.10.619
PubMed:	View item in PubMed

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