Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

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Item Type:	Article
Title:	Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
Creators Name:	Musti, A.M., Treier, M. and Bohmann, D.
Abstract:	The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.
Keywords:	3T3 Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cell Cycle Proteins, GTP-Binding Proteins, Gene Expression Regulation, JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases, Phosphorylation, Proto-Oncogene Proteins C-Jun, Saccharomyces Cerevisiae Cdc42 GTP-Binding Protein, Signal Transduction, Transfection, Ubiquitins, Animals, Mice
Source:	Science
ISSN:	0036-8075
Publisher:	American Association for the Advancement of Science
Volume:	275
Number:	5298
Page Range:	400-402
Date:	17 January 1997
Official Publication:	https://doi.org/10.1126/science.275.5298.400
PubMed:	View item in PubMed

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