Murine inner cell mass-derived lineages depend on Sall4 function

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Item Type:	Article
Title:	Murine inner cell mass-derived lineages depend on Sall4 function
Creators Name:	Elling, U., Klasen, C., Eisenberger, T., Anlag, K. and Treier, M.
Abstract:	Sall4 is a mammalian Spalt transcription factor expressed by cells of the early embryo and germ cells, an expression pattern similar to that of both Oct4 and Sox2, which play essential roles during early murine development. We show that the activity of Sall4 is cell-autonomously required for the development of the epiblast and primitive endoderm from the inner cell mass. Furthermore, no embryonic or extraembryonic endoderm stem cell lines could be established from Sall4-deficient blastocysts. In contrast, neither the development of the trophoblast lineage nor the ability to generate trophoblast cell lines from murine blastocysts was impaired in the absence of Sall4. These data establish Sall4 as an essential transcription factor required for the early development of inner cell mass-derived cell lineages.
Keywords:	Blastocyst, Spalt, Stem Cells, Transcription Factor, Animals, Mice
Source:	Proceedings of the National Academy of Sciences of the United States of America
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Volume:	103
Number:	44
Page Range:	16319-16324
Date:	31 October 2006
Additional Information:	Copyright © 2006 by The National Academy of Sciences of the USA
Official Publication:	https://doi.org/10.1073/pnas.0607884103
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