Dominant reduced responsiveness controlled by H-2(Kb)Ab. A new pattern evoked by Thy-1 antigen and F liver antigen

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Item Type:	Article
Title:	Dominant reduced responsiveness controlled by H-2(Kb)Ab. A new pattern evoked by Thy-1 antigen and F liver antigen
Creators Name:	Mitchison, N.A. and Simon, K.
Abstract:	In the most frequently used panel of H-2 recombinant strains, B10.A, B10.A(4R), B10.A(5R), and B10, inhibition of the immune response has hitherto mapped to H-2E. Inhibition of the responses to Thy-1 antigen and to F liver protein, as described here, maps in a novel pattern to H-2KbAb, and presumably to H-2Ab. Enhancement of the adoptively transferred anti-Thy-1 response by treatment with CD8-specific antibody suggests, very provisionally, that T cells with suppressive activity mediate the inhibition. The evolution of this new pattern, and of dominant reduced responsiveness in general, is discussed and its relevance to immunological diseases assessed. An enzyme-linked immunosorbent assay (ELISA) for F-specific antibodies is introduced.
Keywords:	Immune Response, Immunosorbent Assay, Recombinant Strain, Suppressive Activity, Liver Protein, Animals, Mice
Source:	Immunogenetics
ISSN:	0093-7711
Publisher:	Springer
Volume:	32
Number:	2
Page Range:	104-9
Date:	August 1990
Official Publication:	https://doi.org/10.1007/BF00210447
PubMed:	View item in PubMed

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