Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice

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Item Type:	Article
Title:	Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice
Creators Name:	Jones, E., Dahm-Vicker, M., Simon, A.K., Green, A., Powrie, F., Cerundolo, V. and Gallimore, A.
Abstract:	Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by binding to tumour-specific effector cells. Using a murine model of melanoma we have found that treatment of mice with anti-CD25 mAb facilitates long-term CD4+ T cell-mediated tumour immunity through depletion of CD25+ regulatory cells. We further show that the effector CD4+ T cells confer long-term tumour immunity even in the presence of CD25+ regulatory cells and do not require CD8+ T cells for tumour rejection. The inhibitory impact of anti-CD25 mAb treatment on tumour growth may be the result of depleting CD25+ regulatory cells that normally inhibit the generation of immune responses to self-antigens that are shared by the tumour. We have performed experiments to determine whether or not immune responses to melanocyte antigens are generated in anti-CD25 mAb-treated, melanoma-immune mice. The results of the experiments indicate that a T cell response to the melanocyte antigen tyrosinase accompanies suppression of tumour growth in mice lacking CD25+ regulatory cells.
Keywords:	Animal Disease Models, CD4-Positive T-Lymphocytes, Cultured Tumor Cells, Differentiation Antigens, Genetic Vectors, Immunotherapy, Inbred C57BL Mice, Interleukin-2 Receptors, Melanoma, Monoclonal Antibodies, Monophenol Monooxygenase, Neoplasm Transplantation, Recombinant Proteins, Second Primary Neoplasms, T-Lymphocytes, Vaccinia virus / Genetics, Animals, Mice
Source:	Cancer Immunity
ISSN:	1424-9634
Publisher:	Academy of Cancer Immunology
Volume:	2
Page Range:	1
Date:	February 2002
Official Publication:	https://doi.org/
PubMed:	View item in PubMed

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