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Nonredundant role of Atg7 in mitochondrial clearance during erythroid development

Item Type:Article
Title:Nonredundant role of Atg7 in mitochondrial clearance during erythroid development
Creators Name:Mortensen, M. and Simon, A.K.
Abstract:Autophagy is crucial during tissue development, as the developing cell has to constantly adapt to cell-intrinsic and environmental changes. For instance, protein aggregates need to be cleared, superfluous organelles removed and cell shape adapted to the new function of the cell. One typical example of such a developmental adaptation is that of the red blood cell (RBC). In order to reach the smallest capillaries, the RBC has to reduce its size considerably and the nucleus is expelled from the developing RBC. However, it is still unclear how unwanted proteins, RNA and organelles are cleared during erythroid development. Using an autophagy-deficient murine model we show that mitophagy plays a nonredundant role in the developmental clearance of mitochondria in the erythroid lineage.
Keywords:Atg7, Mitophagy, Red Blood, Cells, Erythroid Cells, Development, T Lymphocytes, Animals, Mice
Source:Autophagy
ISSN:1554-8627
Publisher:Landes Bioscience
Volume:6
Number:3
Page Range:423-5
Date:1 April 2010
Official Publication:https://doi.org/10.4161/auto.6.3.11528
PubMed:View item in PubMed

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